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KMID : 0363420060200010069
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Journal of Korean Oriental Pediatrics
2006 Volume.20 No. 1 p.69 ~ p.83
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Anti-histamic Effect and IL-4 and GM-CSF mRNA Expression on Sungmagalkun-tang
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Kim Hong-Bae
Kim Won-Il
Lee Seung-Yeon
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Abstract
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We investigated the effect of Sungmagalkun-tang (SGT) on the allergy. We conformed compound 48/80-induced active systemic anaphylatic shock, anti-dinitrophenyl IgE-mediated passive cutaneous anaphylaxis and ovalbumin-induced anaphylatic shock. Also observed IL-4 and GM-CSF mRNA expression in ovalbumin-induced allergic lung tissue and RBL-2H3. Histamine release is measured in RBL-2H3. SGT inhibited active systemic anaphylatic shock, passive cutaneous anaphylaxis and ovalbumin-induced anaphylatic shock by oral administration. We observed that SGT was concentration-dependently reduced IL-4 and GM-CSF mRNA expression in ovalbumin-induced allergic lung tissue and RBL-2H3 by SGT. In addition, SGT reduced histamine release in RBL-2H3. These results indicate that SGT has anti-histamic effect and controls IL-4 and GM-CSF mRNA expression on allergy.
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KEYWORD
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Sungmagalkun-tang(SGT), Anti-histamic Effect, IL-4, GM-CS
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